The central weakness is that the science involved is rather provisional. To say "the science isn’t settled" may be a misleading cliché in the global warming debate, but it’s true enough with regard to scientific understanding of ideological differences, and particularly for efforts to analyze such differences in neurobiological terms.
… Mooney makes various acknowledgements of scientific uncertainties and ambiguities. But such disclaimers count for little in a book titled The Republican Brain: The Science of Why They Don’t Believe in Science. The book’s hedging will not prevent conservatives from reacting to the argument with outrage. Nor will it deter liberal readers from gloating that science has delivered some supposed body blow to the entire conservative enterprise.