Michael Grunwald finds little reason to think so:

[F]or all the punditry about a coming Republican civil war, it’s not clear that the party really wants to change in any serious way — or that it could change if it wanted to. Even GOP elites, while concerned that winnable races are being sacrificed on the altar of extremism, suggest that the party is likely to stay the course that worked in 2010. Congressman Tom Cole of Oklahoma, a former Republican political consultant, has been a consistent voice for pragmatism over purity inside the party, but he doesn’t foresee any radical shifts after Tuesday’s split decision. “It’s sobering that we’re throwing away Senate seats. But I don’t see a great schism,” Cole says. “I see a very unified, very conservative party that’s very alarmed about the growth of government. Who would be the generals in our great civil war?”