No matter what motivates you—realpolitik, humanitarianism, nationalism, whatever—interventionism doesn’t make sense if it doesn’t work. And the lesson of the past decade, at the very least, is that interventionism is really, really hard to do well, even if your bar for “well” is really, really low.
The first question for any kind of action in any sphere of human behavior is, will it work? If the answer is yes, then you can move on to arguments about when, whether, and what kind of action might be appropriate. But if the answer is no, all those arguments are moot. In the case of U.S. military interventions, the answer might not quite be an unqualified no, but it sure seems to be pretty damn close. This makes the rest of the argument futile.