Miles Klee considers accidental and involuntary highs:
Any number of drugs can flood our consciousness with faulty perceptions. And if the sensory apparatus isn’t filtering properly, you receive an excess of environmental information when you’re least equipped to handle it. This helps explain why the same drug can generate wildly different results—a CIA field agent whose coffee is secretly spiked with LSD might run screaming into the street, while college buddies can drop a tab and spend all day giggling in a grassy field. The recreational drug user in theory understands that she is messing with her own head. The man who doesn’t know he’s been dosed may conclude that existence has been usurped by mere chaos.