Will Karzai Survive His Presidency?

Jon Lee Anderson is asking:

In Afghanistan’s politics, it has become a question of not if, but when, your killers come for you. At the rate things are going, Hamid Karzai himself will be fortunate to survive his Presidency. A few days back, a suicide bomber exploded himself at his brother’s funeral. Four mourners were killed and several wounded, but luckily for Karzai, he and his other family members were unhurt. In fact, homicide is the odds-on likeliest way to leave office for Afghan’s President. Four out of Afghanistan’s last six leaders have been murdered, three of them in office.

In related commentary, Fred Kaplan says the murder of Karzai's brother "may bode ill for the course of the entire war."