Martin Rees contemplates them:
Einstein averred that "the most incomprehensible thing about the universe is that it is comprehensible". He was right to be astonished. It seems surprising that our minds, which evolved to cope with life on the African savannah and haven’t changed much in 10,000 years, can make sense of phenomena far from our everyday intuitions: the microworld of atoms and the vastness of the cosmos. But our comprehension could one day "hit the buffers". A monkey is unaware that atoms exist. Likewise, our brainpower may not stretch to the deepest aspects of reality.
The Dish 