When inhaled, nicotine travels from lung to brain in an estimated seven seconds. Toxicologists estimate that a fully smoked cigarette delivers about 1 mg of nicotine to the lungs; this compares to a lethal dose estimate of 30-60 mg. (For further comparison, the lethal dose range for arsenic is 70-200 mg.) The International Programme on Chemical Safety (IPCS) notes that: "Nicotine is one of the most toxic of all poisons and has a rapid onset of action. Apart from local caustic actions, the target organs are the peripheral and central nervous systems."
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The Dish 