Early studies suggested that fish oil has major health benefits, but later research found little effect. Keith Humphreys explains how this happens:
For a small study (such as Sacks’ and Leng’s early work in the top two rows of the table) to get published, it needs to show a big effect — no one is interested in a small study that found nothing. It is likely that many other small studies of fish oil pills were conducted at the same time of Sacks’ and Leng’s, found no benefit and were therefore not published. But by the play of chance, it was only a matter of time before a small study found what looked like a big enough effect to warrant publication in a journal editor’s eyes.
At that point in the scientific discovery process, people start to believe the finding, and null effects thus become publishable because they overturn “what we know”. And the new studies are larger, because now the area seems promising and big research grants become attainable for researchers. Much of the time, these larger and hence more reliable studies cut the “miracle cure” down to size.
The Dish 