Brian Anderson explores the potential of “micro-dosing” LSD, which would allow you to possibly “reap some of the reported benefits of a semisynthetic psychedelic like LSD without going all heavyminded”:
That’s the allure of what’s known as the sub-perceptual dose. It’s an idea that has been gaining traction in certain pockets of the medical community, though it’s neither new nor validated by any formal research. As James Fadiman notes in The Psychedelic Explorer’s Guide (2011), sub-perceptual psychedelic dosings have for centuries been known about and utilized by indigenous cultures the world over. Fadiman would know. He’s been in the trenches of legitimate mind-altering research for over four decades, and with time has become a sort of champion of the micro dose.
The problem – as usual – is prohibition’s effect on research:
[Fadiman] can’t establish proper lab conditions without facing criminal charges. The workaround? His volunteers must access the Schedule 1 drug on their own, and then parse the stuff into micro-hits of either 50 or 100 micrograms. Then they self adminster, and finally self-report. And then they repeat.
More Dish on drug research and micro-hits here, here, and here.